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Akkermansia muciniphila

Akkermansia muciniphila is commonly found in the human gut, generally at an abundance of 1-7% of the total bacterial population. This species of bacteria seems to have an interesting association with weight. Scientists have shown that Akkermansia muciniphila is 3,300 times less present in the guts of mice genetically predisposed to obesity than in normal rodents. Similar observations have been made in humans: when people have a lot of Akkermansia muciniphila in their guts, they tend to be slimmer.

Akkermansia muciniphila (pronounced “acker-MAN-see-ah MEW-sin-ee-FILL-ah”) was first isolated in 2004. The name of its genus, Akkermansia, comes from the Dutch microbiologist Antoon Akkermans in recognition of his contribution to microbial ecology. The species name, muciniphila, means “mucus-loving”, since this bacteria feeds on the mucus that lines the inner surfaces of the intestine.

The species is considered a probiotic bacterium with anti-inflammatory properties.

References 

1. Derrien, M., Vaughan, E. E., Plugge, C. M., & Vos, W. M. De. (2004). Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium Muriel. International Journal of Systematic and Evolutionary Microbiology, 54, 1469–1476.  

2. Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., & Guiot, Y. (2013). Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. PNAS, 110(22), 9067–9071. 

3. Maier, E., Anderson, R. C., & Roy, N. C. (2015). Understanding How Commensal Obligate Anaerobic Bacteria Regulate Immune Functions in the Large Intestine. Nutrients, 7, 45–73.




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