Which uBiome product is right for you?

SmartGut

Doctor-ordered gut health test

SmartJane

Doctor-ordered women’s health test

Explorer

Discover your microbiome without the help of a doctor

Who is it for?

Patients with chronic gut conditions such as IBD or IBS, or symptoms such as gas, bloating or diarrhea.

Patients with the desire to, alongside their healthcare provider, learn more about their own vaginal health and how to improve conditions, such as discharges or infections, through lifestyle or diet.

Health and wellness tool to help you better discover how diet and lifestyle affect your microbiome.

Doctor authorization required?

Yes

Yes

No

Where is it available?

US and Canada (other countries coming soon)

US and Canada (other countries coming soon)

203 countries and regions where online payments can be made with a credit card or PayPal

What is the price?

uBiome clinical tests are fully or partially covered by most health insurance companies under “out-of-network” healthcare benefits. We have patient assistance programs in place to assist eligible patients with the remaining patient responsibility.

uBiome clinical tests are fully or partially covered by most health insurance companies under “out-of-network” healthcare benefits. We have patient assistance programs in place to assist eligible patients with the remaining patient responsibility.

From $89 for one site to $399 for five sites.

Targeted at which body site(s)?

Gut microbiome exclusively

Vaginal microbiome

Gut, nose, oral, skin or genital microbiome.

Suitable for other sampling purposes?

SmartGut is solely for adult gut samples.

SmartJane is solely for adult vaginal samples

Yes! Sample kids, pets, home environment, etc.

Any age requirements?

Available to all ages, parental permission needed if under 18.

Available to everyone aged 18 years and older.

Available to all ages, parental permission needed if under 18.

How is sample collected?

Easy self-sampling at home, takes under three minutes.

Easy self-sampling at home, takes under three minutes.

Easy self-sampling at home, takes under three minutes.

What do results show?

Detects beneficial and pathogenic microorganisms associated with specific infections, lifestyle choices, and gut conditions including Inflammatory Bowel Disease (IBD) and irritable bowel syndrome (IBS).

Detects beneficial and pathogenic microorganisms associated with specific infections, such as cervicitis, bacterial vaginosis or vaginitis.

Interactive online tools enable you to explore how your microbiome compares to others, and to monitor yourself over time.

Where does processing take place?

In our San Francisco laboratory, which is CLIA-certified and accredited by the College of American Pathologists (CAP), a standard only achieved by the top 3% of laboratories in the world.

In our San Francisco laboratory, which is CLIA-certified and accredited by the College of American Pathologists (CAP), a standard only achieved by the top 3% of laboratories in the world.

In our San Francisco laboratory, which is CLIA-certified and accredited by the College of American Pathologists (CAP), a standard only achieved by the top 3% of laboratories in the world.

Can you participate in scientific research?

Optionally enables you to anonymously participate in scientific research aimed at advancing understanding of the human microbiome.

Optionally enables you to anonymously participate in scientific research aimed at advancing understanding of the human microbiome.

Optionally enables you to anonymously participate in scientific research aimed at advancing understanding of the human microbiome.

Your gut has something to tell you.

Smart, actionable insights to improve your gut health. Learn more.

What is chronic rhinosinusitis?

Sinuses are hollow, connected cavities in the skull located in the cheekbones, forehead, between the eyes, and in bones behind the nose. It is believed that sinuses help humidify and filter the air we breathe in. Normally, these cavities are lined with a thin layer of mucus and are otherwise empty. Chronic rhinosinusitis (CRS, or sinusitis) occurs when the lining of the nose and sinuses is constantly inflamed. This often results in mucus building up in the sinuses and an uncomfortable sensation of pressure in the front of the face.1,2 CRS can severely impact quality of life and make it difficult to work.1

About 10-15% of people worldwide have CRS. According to The National Health Interview Survey, 12.1% of adults in the US had CRS in 2012.3

What are common symptoms?

A doctor may diagnose you with CRS if you have been experiencing two or more of the main symptoms for at least 3 months. These main symptoms include4:

  • Nasal congestion caused by mucus
  • Nasal drainage
  • Loss of smell
  • Facial pain or sensation of pressure

Other symptoms include headache, fever, coughing, bad breath, fatigue, ear fullness, ear pain, and ear pressure. As CRS worsens, it can change the structure of the sinuses, leading to asthma and migraines.4

You may be at risk for CRS if you have any of the following (in order of frequency)5:

  • Allergies
  • Deviated septum and other changes to facial structure
  • Asthma
  • Aspirin sensitivity
  • Immune system disorders
  • Viral infections
  • Sinus surgery history

You may also be at risk of CRS if you have been exposed to one or more of these conditions (in order of frequency)5,6,7:

  • Smoking
  • Air pollutants
  • Damp environments
  • Wintery conditions

What are the causes?

Though we don’t yet know the exact cause of CRS, scientists have some theories. The environment you live in may affect whether you develop the disease. For example, researchers are studying whether certain fungi and bacteria can trigger the disorder. How well your immune response functions may also affect your likelihood of developing CRS. If your immune response is defective, your skin barrier may not function properly and you may struggle to clear your respiratory tract. These factors may work together to cause inflammation in your nose and sinuses and eventually cause CRS to develop.2,8

How does this topic relate to my microbiome?

Scientists are using new, advanced techniques to explore the relationship between CRS and a dysfunctional nasal microbiome.8 Studies generally show that CRS patients have an unhealthy microbiome in their sinuses, with lower microbial diversity, compared to healthy controls. Healthy individuals’ nasal microbiota are mostly populated by the phyla Propionibacterium, Actinobacter, or Burkholderia. Scientists believe that these bacteria help maintain a stable microbiota in the sinuses and can prevent CRS from developing or progressing. The bacteria most commonly associated with CRS are those belonging to the phylum Staphylococcus (especially S. aureus), Corynebacterium, and Streptococcus.9,10

Which diseases/topics are related to chronic rhinosinusitis?

Since CRS involves inflammation, it is associated with several other respiratory conditions, including:

  • Asthma
  • Allergic rhinitis
  • Chronic obstructive pulmonary disease (COPD)
  • Influenza
  • Viral upper respiratory infections

How can I take action?

Chornic rhinosinusitis patients often need lifelong treatment to control their symptoms. Some measures you can take on your own if you suffer from CRS are (in order of importance)11:

  • Quitting smoking
  • Reducing exposure to allergens at home and in the workplace
  • Washing nasal passages with saline solution

For a correct evaluation of your condition, visit your healthcare provider. Depending on what is causing your CRS, they may recommend:

  • Allergy treatments
  • Antibiotics, if a bacterial infection is causing your CRS
  • Glucocorticoid treatment (intranasal or oral)
  • Surgery, if your CRS is severe, or caused by anatomic problems or nasal polyposis11

References

1. Tomassen, P., Zele, T. V., Zhang, N., Perez-Novo, C., Bruaene, N. V., Gevaert, P., & Bachert, C. (2011). Pathophysiology of Chronic Rhinosinusitis. Proceedings of the American Thoracic Society, 8(1), 115–120.

2. Stevens, W. W., Lee, R. J., Schleimer, R. P., & Cohen, N. A. (2015). Chronic rhinosinusitis pathogenesis. Journal of Allergy and Clinical Immunology, 136(6), 1442–1453.

3. DeConde, A. S., & Soler, Z. M. (2016). Chronic rhinosinusitis: Epidemiology and burden of disease. American Journal of Rhinology and Allergy, 30(2), 134–139.

4. Sundaresan, A. S., Hirsch, A. G., Young, A. J., Pollak, J., Tan, B. K., Schleimer, R. P., … Schwartz, B. S. (2018). Longitudinal Evaluation of Chronic Rhinosinusitis Symptoms in a Population-Based Sample. Journal of Allergy and Clinical Immunology: In Practice, 6(4), 1327–1335.e3.

5. Tint, D., Kubala, S., & Toskala, E. (2016). Risk Factors and Comorbidities in Chronic Rhinosinusitis. Current Allergy and Asthma Reports, 16(2), 16.

6. Ahlroth Pind, C., Gunnbjörnsdottír, M., Bjerg, A., Järvholm, B., Lundbäck, B., Malinovschi, A., … Janson, C. (2017). Patient-reported signs of dampness at home may be a risk factor for chronic rhinosinusitis: A cross-sectional study. Clinical & Experimental Allergy, 47(11), 1383–1389.

7. Mady, L. J., Schwarzbach, H. L., Moore, J. A., Boudreau, R. M., Willson, T. J., & Lee, S. E. (2018). Air pollutants may be environmental risk factors in chronic rhinosinusitis disease progression. International Forum of Allergy & Rhinology, 8(3), 377–384.

8. Lam, K., Schleimer, R., & Kern, R. C. (2016). The Etiology and Pathogenesis of Chronic Rhinosinusitis: a Review of Current Hypotheses, 15(7).

9. Wagner Mackenzie, B., Waite, D. W., Hoggard, M., Douglas, R. G., Taylor, M. W., & Biswas, K. (2017). Bacterial community collapse: a meta-analysis of the sinonasal microbiota in chronic rhinosinusitis. Environmental Microbiology, 19(1), 381–392.

10. Cleland, E. J., Bassiouni, A., Vreugde, S., & Wormald, P. J. (2016). The bacterial microbiome in chronic rhinosinusitis: Richness, diversity, postoperative changes, and patient outcomes. American Journal of Rhinology and Allergy, 30(1), 37–43.

11. Scadding, G. K., Durham, S. R., Mirakian, R., Jones, N. S., Drake-Lee, A. B., Ryan, D., … Nasser, S. M. (2007). The bacterial microbiome in chronic rhinosinusitis: BSACI guidelines for the management of rhinosinusitis and nasal polyposis. Clinical & Experimental Allergy, 38(2), 260–275.